This textbook from Paras Medical Publisher is an English medium (अंग्रेजी माध्यम) book on Pharmacology, written by HL Sharma and KK Sharma, prepared for MBBS students as per the CBME curriculum, and also useful for BDS, nursing, pharmacy and allied health science courses. This Fourth Edition is written around principles rather than lists — the mechanisms that govern how drugs act, how they are handled by the body and how they are chosen for a patient are established first, and each drug group is then explained as an application of those principles (मूल सिद्धांत), which is what allows a student to reason through an unfamiliar drug in the examination instead of recalling it. The book covers general pharmacology with pharmacokinetics, pharmacodynamics, receptors and signal transduction, routes of administration, drug interactions and adverse drug reactions; autonomic nervous system drugs; autacoids and NSAIDs; cardiovascular drugs including antihypertensives, antianginals, antiarrhythmics and heart failure drugs; diuretics; drugs acting on blood; respiratory and gastrointestinal pharmacology; central nervous system drugs including general and local anaesthetics, sedatives, antiepileptics, antipsychotics, antidepressants and opioid analgesics; endocrine pharmacology including insulin, oral antidiabetics, corticosteroids and thyroid drugs; chemotherapy of infections and malignancy; immunopharmacology; and toxicology with the management of common poisonings. Its distinguishing feature is this concept-first approach taught by two long-standing teachers of the subject, supported by diagrams, flowcharts and comparison tables that make revision quick. All content, terminology and explanations in this book are presented in the English language only. Key Features: English medium book — complete content, terminology and explanations in English Written by HL Sharma and KK Sharma, published by Paras Medical Publisher Fourth Edition, revised and updated As per the CBME curriculum Concept-based treatment — principles established first, drug groups explained as applications Mechanisms explained so that unfamiliar drugs can be reasoned through Clinical application given alongside each drug group Diagrams, flowcharts and comparison tables for quick visual learning Designed for MBBS students; also useful for BDS, nursing, pharmacy and allied health courses General pharmacology — pharmacokinetics, pharmacodynamics and routes of administration Receptors, signal transduction and drug–receptor interactions Adverse drug reactions, drug interactions and pharmacovigilance Autonomic nervous system pharmacology Autacoids, NSAIDs and drugs used in gout and rheumatoid arthritis Cardiovascular drugs — antihypertensives, antianginals, antiarrhythmics and heart failure drugs Diuretics and drugs acting on the kidney Drugs acting on blood — anticoagulants, antiplatelets and haematinics Respiratory and gastrointestinal pharmacology Central nervous system — anaesthetics, sedatives, antiepileptics, antipsychotics, antidepressants and opioids Endocrine pharmacology — insulin, oral antidiabetics, corticosteroids and thyroid drugs Chemotherapy — antibiotics, antitubercular, antimalarial, antifungal, antiviral and anticancer drugs Immunopharmacology and vaccines Toxicology and management of common poisonings Useful for MBBS university/professional examinations, internal assessments, viva and NEET PG preparation MBBS विद्यार्थियों के लिए Paras Medical Publisher द्वारा प्रकाशित यह "Sharma & Sharma's Principles of Pharmacology" (4th Edition) पुस्तक HL Sharma एवं KK Sharma द्वारा लिखी गई है तथा CBME पाठ्यक्रम के अनुसार है; यह BDS, नर्सिंग, फार्मेसी एवं अन्य allied health science विद्यार्थियों के लिए भी उपयोगी है। इसमें सामान्य औषध विज्ञान, receptors एवं signal transduction, स्वायत्त तंत्रिका तंत्र, autacoids एवं NSAIDs, हृदय-रक्तवाहिका औषधियाँ, diuretics, रक्त, श्वसन एवं पाचन तंत्र की औषधियाँ, केंद्रीय तंत्रिका तंत्र की औषधियाँ, अंत:स्रावी औषध विज्ञान, संक्रमण व कैंसर की chemotherapy, immunopharmacology तथा विष विज्ञान को मूल सिद्धांतों के आधार पर चित्रों, फ्लोचार्ट्स एवं तुलनात्मक तालिकाओं सहित समझाया गया है। सम्पूर्ण पुस्तक अंग्रेजी माध्यम (English medium) में है, इसमें हिंदी माध्यम की सामग्री सम्मिलित नहीं है।