This reference manual from Jaypee Brothers Medical Publishers is an English medium (अंग्रेजी माध्यम) book on drug screening, written by SK Gupta, prepared for postgraduate students of pharmacology and pharmacy (MD Pharmacology, M.Pharm, PhD), research scholars, and scientists working in drug discovery and preclinical evaluation, and also useful to undergraduate pharmacy and medical students being introduced to experimental pharmacology. This Third Edition brings together, in one place, the screening models used to test a new molecule before it reaches a human being — organised into primary screening and further evaluation, and within each into in vitro and in vivo methods (जैव-परीक्षण विधियाँ), with every model given as a working protocol stating its principle, the animals or preparations required, the drugs and reagents, the stepwise procedure, the parameters observed, the statistical evaluation and the limitations of the method. The book covers general principles of screening and biostatistics in preclinical research, laboratory animal handling, ethics and CPCSEA requirements, and then the system-wise models: analgesic, anti-inflammatory and antipyretic screening, CNS screening including anticonvulsant, antidepressant, antipsychotic, anxiolytic and nootropic models, autonomic and neuromuscular preparations, cardiovascular screening including antihypertensive, antiarrhythmic and antianginal models, respiratory and antiasthmatic models, gastrointestinal and antiulcer models, antidiabetic and endocrine screening, diuretic and renal models, hepatoprotective, antioxidant and immunomodulatory assays, antimicrobial, antiviral and anticancer screening, and toxicity studies covering acute, subacute, chronic, genotoxicity, teratogenicity and carcinogenicity testing. Its distinguishing feature is this protocol-first arrangement of a very large number of validated models in a single volume. All content, terminology and explanations in this book are presented in the English language only.
Key Features:
English medium book — complete content, terminology and explanations in English
Written by SK Gupta, published by Jaypee Brothers Medical Publishers
Third Edition, revised and updated
Comprehensive reference manual of in vitro and in vivo drug screening models
Every model given with principle, requirements, procedure, parameters, evaluation and limitations
Screening models arranged system by system for easy selection
Statistical evaluation of experimental data explained
Laboratory animal handling, ethics and CPCSEA requirements covered
Diagrams, flowcharts and tables for laboratory use
Written for MD Pharmacology, M.Pharm, PhD scholars and preclinical researchers
Also useful for undergraduate pharmacy and medical students
General principles of drug screening and preclinical evaluation
Analgesic, anti-inflammatory and antipyretic screening models
CNS models — anticonvulsant, antidepressant, antipsychotic, anxiolytic and nootropic
Autonomic and neuromuscular preparations
Cardiovascular models — antihypertensive, antiarrhythmic and antianginal screening
Respiratory and antiasthmatic screening models
Gastrointestinal and antiulcer models
Antidiabetic and endocrine screening models
Diuretic and renal function models
Hepatoprotective, antioxidant and immunomodulatory assays
Antimicrobial, antiviral and anticancer screening
Toxicity studies — acute, subacute, chronic, genotoxicity, teratogenicity and carcinogenicity
Useful for postgraduate practical examinations, thesis and dissertation work and preclinical research
Pharmacology एवं Pharmacy के स्नातकोत्तर विद्यार्थियों, शोधार्थियों तथा preclinical अनुसंधान से जुड़े वैज्ञानिकों के लिए Jaypee Brothers Medical Publishers द्वारा प्रकाशित यह "Drug Screening Methods" (3rd Edition) पुस्तक SK Gupta द्वारा लिखी गई है; यह स्नातक स्तर के pharmacy एवं medical विद्यार्थियों के लिए भी उपयोगी है। इसमें drug screening के सामान्य सिद्धांत, प्रयोगशाला पशु संचालन एवं CPCSEA नियम, तथा analgesic, anti-inflammatory, CNS, autonomic, हृदय-रक्तवाहिका, श्वसन, पाचन, antidiabetic, diuretic, hepatoprotective, antioxidant, immunomodulatory, antimicrobial एवं anticancer screening मॉडलों के साथ-साथ acute, subacute, chronic, genotoxicity एवं teratogenicity विषाक्तता अध्ययनों को principle, procedure, parameters एवं evaluation सहित समझाया गया है। सम्पूर्ण पुस्तक अंग्रेजी माध्यम (English medium) में है, इसमें हिंदी माध्यम की सामग्री सम्मिलित नहीं है।
